Fig. 5From: ΔPSap4#5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigationIn vitro evaluation of cellular uptake, cytotoxicity, and apoptosis in 22Rv1 cells. A FACS histogram for cellular uptake measurement after the treatment with ABR-NP and Apt-ABR-NP at 6 h and 12 h. B IC50 values of ABR, ABR-NP, and Apt-ABR-NP on 22Rv1 cells (data show mean ± SD, n = 3; * indicates p<0.05 when compared against ABR- treated group of mice), and C induction of apoptosis in 22Rv1 cells after treatment with ABR, ABR-NP, and Apt-ABR-NP for 48 hBack to article page