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Fig. 8 | Cancer Nanotechnology

Fig. 8

From: ΔPSap4#5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigation

Fig. 8

Hemolytic activity and pharmacokinetic profile of ABR, ABR-NP, and Apt-ABR-NP. A Hemolytic activity of ABR, ABR-NP, and Apt-ABR-NP was measured by incubating each sample with red blood cells and measuring the amount of hemoglobin released. The percentage of hemolysis was plotted against the concentration of the samples. Data show mean ± SD (n = 3) where p < 0.05 is the statistical level of significance as assessed by Dunnett’s test (compared against control group). B The pharmacokinetic profile of ABR, ABR-NP, and Apt-ABR-NP was assessed in mice by measuring the concentration of ABR from each sample in the bloodstream over time. The data were plotted as the mean concentration of each sample at each time point. Error bars indicate standard deviation (n = 3). *Marks represent significant values (p < 0.05) when ABR-NP and Apt-ABR-NP were compared with ABR through the two-way ANOVA test, and the statistical significance of data was analyzed through Bonferroni's post-test

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Cancer Nanotechnology

ISSN: 1868-6966

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