Parameters | ABR | ABR-NP | Apt-ABR-NP |
---|---|---|---|
Cmax (ng/ml) | 25 ± 2.5 | 30 ± 2.5* | 32 ± 2.4* |
Tmax (h) | 2.0 ± 0.2 | 9.0 ± 0.4* | 9.0 ± 0.5* |
AUC last (ng h/ml) | 547 ± 27 | 1204 ± 167* | 1356 ± 175* |
AUC 0–∞ (ng h/ml) | 582 ± 30 | 1672 ± 175* | 1975 ± 194* |
AUMC (ng h2/ml) | 12,345 ± 416 | 34,325 ± 544* | 39,603 ± 622* |
T1/2 (h) | 12 ± 0.4 | 36 ± 1.7* | 39 ± 2.2* |
MRT (h) | 22.5 ± 1.1 | 28.5 ± 1.6* | 29.2 ± 1.2* |
Vd (ml) | 316 ± 10 | 430 ± 12* | 415 ± 20* |
Clearance (ml/h) | 18.2 ± 0.9 | 8.3 ± 0.8* | 7.4 ± 0.2* |