Skip to main content

Table 2 Biodistribution of 99mTc-ABR-NP and 99mTc-Apt-ABR-NP in testosterone/MNU-induced prostate cancer-bearing mice

From: ΔPSap4#5 surface-functionalized abiraterone-loaded nanoparticle successfully inhibits carcinogen-induced prostate cancer in mice: a mechanistic investigation

Organ/tissue

%ID of 99mTc-ABR-NP in CRPC mice

%ID of 99mTc-Apt-ABR-NP in CRPC mice

1 h

2 h

5 h

1 h

2 h

5 h

Blood#

3.882 ± 0.01

3.601 ± 0.22

3.228 ± 0.28

4.156 ± 0.31

3.946 ± 0.31

3.644 ± 0.42

Heart

0.545 ± 0.12

0.602 ± 0.05

0.664 ± 0.04

0.712 ± 0.03

0.722 ± 0.07

0.730 ± 0.04

Liver

20.12 ± 2.10*

24.55 ± 2.00*

22.44 ± 4.34*

23.60 ± 2.55*

26.04 ± 2.01*

30.58 ± 1.80*

Lungs

0.563 ± 0.21

0.578 ± 0.23

0.606 ± 0.32

0.688 ± 0.20

0.894 ± 0.20

1.142 ± 0.33

Stomach

0.448 ± 0.16

0.382 ± 0.10

0.404 ± 0.11

0.725 ± 0.10

0.784 ± 0.11

0.942 ± 0.20

Intestine

2.762 ± 0.51

2.920 ± 0.31

3.752 ± 0.30

3.114 ± 0.12

3.205 ± 0.55

4.025 ± 0.62

Kidney

3.452 ± 0.30

4.348 ± 0.42

7.88 ± 0.528*

4.565 ± 0.45*

7.14 ± 0.642*

10.24 ± 0.47*

Prostate

1.642 ± 0.21

1.811 ± 0.16*

2.313 ± 0.22*

2.256 ± 0.30

2.622 ± 0.24*

3.142 ± 0.36*

Urine

26.56 ± 3.89*

30.56 ± 2.18*

32.44 ± 2.14*

30.12 ± 1.55*

33.56 ± 2.51*

37.12 ± 3.18*

  1. #Represents %ID/g in the case of blood, otherwise %ID in the whole organ
  2. *Marks represent statistically significant values when both 99mTc-ABR-NP and 99mTc-Apt-ABR-NP were compared for different time points in two-way ANOVA analysis and tested by Bonferroni’s post-test (p < 0.05)