Fig. 4

Photomicrographs showing the histology of the lung epithelium and tumors in the six groups of mice. A Normal mouse lung epithelium from Group 1 (G1). B Alveolar epithelial hyperplasia from Group 2, which was administered with the carcinogen only. Increased thickness of the alveolar epithelial cells is seen in the lesion when compared to the normal lung epithelium. C, D Lung epithelium from Groups 3 and 4, which were treated with BPE and Avastin, respectively. E Lung epithelium from Group 5, which was treated with BPENP. F Lung epithelium from Group 6, which was treated with BPENP + Avastin. The thickness of the hyperplastic alveolar epithelium was reduced after all the treatments, particularly in Group 6, when compared to that in the normal control (Group 1). G Bronchioloalveolar adenoma from Group 2. H Magnified view of an area from G. The sizes of the adenomas were reduced after the treatment with BPE (I), Avastin (J), BPENP (K), or BPENP + Avastin (L). M Bronchioloalveolar adenocarcinomas from Group 2. N magnified view of an area from M. Treatment with BPE (O), Avastin (P), BPENP (Q), or BPENP + Avastin (R) reduced the sizes of the adenocarcinomas compared to that in Group 2