Based polymer nanoparticles from bee pollen attenuate non-small lung cancer through enhancement of apoptosis and cell cycle arrest in vivo

Table 1 Histological incidence (%), multiplicity, and average tumor area per 1 cm² of the lung tissue

Groups	Treatment	Mice (n)	No. of lung tumors ^a	Tumor incidence (%)	Tumor Multiplicity (Number of tumors/1 cm²) ^b	Average tumor areas/1 mm^{2 c}
G1	Control -ve	9	0	0	0	0
G2	Ure + BHT	10	8.40 ± 0.12	9/10 (90%)	6.88 ± 4.2	12.99 ± 13.8
G3	Ure + BHT + BPE	8	6.25 ± 0.17^*	6/8 (75%)	4.28 ± 2.2^*	7.6 ± 3.1 ^*
G4	Ure + BHT + Avastin	12	4.58 ± 0.17^*	7/12 (58.3%)	2.25 ± 2.22^*	4.98 ± 6.4 *
G5	Ure + BHT + BPENP	10	5.20 ± 0.12^*	6/10 (60%)	3.85 ± 3.7^*	6.78 ± 5.8 ^*
G6	Ure + BHT + BPENP + Avastin	8	3.75 ± 0.08^*	4/8 (50%)	1.80 ± 1.0, ,**	3.25 ± 4.3 ^{, ,**}

n, number of animals used in histopathological analysis; Ure, urethane; G1: normal control; G2: Ure + BHT; G3: Ure + BHT + BPE; G4: Ure + BHT + Avastin; G5: Ure + BHT + BPENP; G6: Ure + BHT + BPENP + Avastin. a lesions: total microscopical (histological) lesions in lung tissues in tumor-bearing mice regardless of histological type; b Number of lesions histologically diagnosed as adenomas and adenocarcinomas in 1cm2 of lung tissue; c Areas (mm²) (tumor size) in 1cm² of lung tissues; Values are means ± standard deviation (S.D.). *: Significant vs. G2 at P < 0.05; **: significant vs. G4, ***: significant vs. G5 at P < 0.05

ISSN: 1868-6966