Fig. 4
From: Application of tumor microparticles in tumor prevention and treatment
Schematic showing mechanism by which T-MPs served as i.m. injection vaccine (Sun et al. 2023). (1) After T-MPs were injected into mice, macrophages first took up them and upregulated CCL2 expression. (2) CCL2 drew monocytes in blood to vaccine injection site, increasing the uptake of T-MPs. (3) Monocytes entered draining lymph node, and differentiated into monocyte-derived DCs (moDCs), which promoted T cell-specific proliferation