Fig. 9
From: Application of tumor microparticles in tumor prevention and treatment
Schematic showing drug-loaded T-MP enhancement of anti-tumor responses (Xu et al. 2023). a Steps 1–2; b steps 3–5. (1) Drug-loaded T-MPs were endocytosed by tumor cells and destroyed tumor cells effectively; (2) Neutrophils were activated after endocytosis of drug-loaded T-MPs; (3) Activated neutrophils reduced the expression of PD-1 and promoted T cell activation; (4) Activated neutrophils released ROS and induced the tumor cell apoptosis; (5) Activated neutrophils released elastase to kill tumor cells and destroy matrix, promoting the infiltration of T cells and enhancing anti-tumor response. The red arrow indicates an increase expression, and blue arrow indicates a reduced expression