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Fig. 4 | Cancer Nanotechnology

Fig. 4

From: Polymer lipid hybrid nanoparticles encapsulated with Emodin combined with DOX reverse multidrug resistance of breast cancer via IL-6/JAK2/STAT3 signaling pathway

Fig. 4

Relationship between IL-6 and proliferation, EMT and MDR of MCF-7/ADR cells. A, C Effects of IL-6 and its combination with DOX on the viability of MCF-7/ADR cells; B Effects of IFN- γ and its combination with DOX on the viability of MCF-7/ADR cells; D, E. Effects of IL-6 on the expression of apoptosis related proteins in MCF-7/ADR cells; F, G. Effects of IL-6 on the expression of EMT related proteins in MCF-7/ADR cells; H, I. Effects of IL-6 on the expression of MDR related proteins in MCF-7/ADR cells. The numerical data (A-D, F, H, J) were presented as the mean ± SD (n = 3). Unpaired two-tailed t test (A, F, H, J) and one-way ANOVA followed by the Bonferroni post hoc test (B–D) were used for statistical significance analysis. All experiments were repeated three times. *p < 0.05, **p < 0.01, ***p < 0.001.

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Cancer Nanotechnology

ISSN: 1868-6966

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