Fig. 5

Effects of AG490 and E-PLNs on IL-6/JAK2/STAT3 signaling pathway in MCF-7/ADR cells. A. Effects of different concentrations of AG490 on viability of MCF-7/ADR cells; B, C. Effects of 40 μM AG490 treatment on the expression of IL-6/JAK2/STAT3 signaling pathway in MCF-7/ADR cells; D. Effects of E-PLNs on the level of secretion of IL-6 and IFN—γ in MCF-7/ADR cells; E–H. Effects of E-PLNs on the expression of IL-6/JAK2/STAT3 signaling pathway in MCF-7/ADR cells. The numerical data (A, C, D, F, H) were presented as the mean ± SD (n = 3). Unpaired two-tailed t test (C) and one-way ANOVA followed by the Bonferroni post hoc test (D, F, H) were used for statistical significance analysis. All experiments were repeated three times. *p < 0.05, **p < 0.01, ***p < 0.001, ns means no significance.