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Fig. 5 | Cancer Nanotechnology

Fig. 5

From: Designing nanostructured lipid carriers modified with folate-conjugated chitosan for targeted delivery of osthole to HT-29 colon cancer cells: investigation of anticancer, antioxidant, and antibacterial activities

Fig. 5

The flow cytometric analysis data of the HT-29 cell line following treatment with 65 and 115 μg/ml of OST-NCF-NPs in comparison to the control. A The cell death rate of HT-29-treated cells. Treatment of HT-29 cells at a dose of 65 and 115 µg/mL for 24 h resulted in 25.59% and 25.11% apoptotic cells compared to untreated cells. Apoptotic cells (PI-, AnV +) were plotted as a percentage of the total cell population. The numbers represent the percentage of viable cells (Q4), early apoptotic cells (Q3), late apoptotic cells (Q2), and necrotic cells (Q1). B) Cell cycle distribution in HT-29-treated cells. Exposure of cells to OST-NCF-NPs increased the proportion of apoptotic cells as reflected by the sub-G1 peak. (Experiments were repeated in triplicate, Mean ± SD). OST-NCF-NPs Nanostructured lipid carriers coated with chitosan-conjugated folate nanoparticles containing Osthole, AnV/PI Annexin V/Propidium Iodide

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Cancer Nanotechnology

ISSN: 1868-6966

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