Designing nanostructured lipid carriers modified with folate-conjugated chitosan for targeted delivery of osthole to HT-29 colon cancer cells: investigation of anticancer, antioxidant, and antibacterial activities

Table 2 The antibacterial activity of OST-NCF-NPs against pathogenic bacteria strains (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) in disk diffusion, MIC, and MBC

	Disk Diffusion		MIC		MBC
	OST-NCF-NPs	Gentamicin	OST-NCF-NPs	Chloramphenicol	OST-NCF-NPs	Chloramphenicol
Bacillus subtilis (PTCC 1365)	10 ± 0.82 mm	22 mm	250 µg/mL	5 µg/mL	500 µg/mL	10 µg/mL
Staphylococcus aureus (ATCC 25923)	13.3 ± 0.47 mm	28.7 ± 0.47 mm	125 µg/mL	5 µg/mL	250 µg/mL	10 µg/mL
Escherichia coli (ATCC 25922)	14 mm	22.7 ± 0.47 mm	31.25 µg/mL	5 µg/mL	62.5 µg/mL	10 µg/mL
Pseudomonas aeruginosa (ATCC 9027)	16.7 ± 0.47 mm	21 mm	31.25 µg/mL	5 µg/mL	62.5 µg/mL	10 µg/mL

(N = 3). OST-NCF-NPs Nanostructured lipid carriers coated with chitosan-conjugated folate nanoparticles containing Osthole, MIC The minimum inhibitory concentration, MBC Minimum bactericide concentration

ISSN: 1868-6966