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Table 2 BBD parameters attained for several runs and trial ranges of PS (nm) and EE (%)

From: Optimization and characterization of quercetin-loaded solid lipid nanoparticles for biomedical application in colorectal cancer

Std.

Run

X1

X2

X3

X4

X5

PS

EE (%)

Actual

Predicted

Actual

Predicted

1

1

25

30

5

5

5

129.32

129.98

97.07

97.52

2

2

75

30

5

5

5

238.1

237.70

97.01

97.37

3

5

25

70

5

5

5

131.38

130.81

98.76

98.24

4

7

75

70

5

5

5

177.98

178.49

97.44

97.66

5

20

50

50

2.5

4

5

119.01

119.28

98.31

98.41

6

37

50

50

7.5

4

5

178.98

178.49

97.51

97.66

7

23

50

50

2.5

6

5

227.12

227.00

97.33

97.34

8

11

50

50

7.5

6

5

136.01

136.05

98.14

98.80

9

19

50

30

5

5

4

113.63

113.21

97.09

97.13

10

29

50

70

5

5

4

161.97

162.21

97.89

97.52

11

39

50

30

5

5

6

194.82

196.09

98.67

98.10

12

26

50

70

5

5

6

136.2

134.73

97.56

97.00

13

9

25

50

2.5

5

5

221.76

220.93

98.25

98.11

14

13

75

50

2.5

5

5

179.2

178.49

97.23

97.66

15

8

25

50

7.5

5

5

177.82

178.49

97.11

97.66

16

33

75

50

7.5

5

5

161.56

161.72

97.9

98.10

17

10

50

50

5

4

4

189.67

190.02

97.02

97.57

18

25

50

50

5

6

4

178.78

178.49

97.42

97.66

19

34

50

50

5

4

6

174.02

173.73

97.59

97.40

20

41

50

50

5

6

6

160.71

160.89

98.43

98.34

21

22

50

30

2.5

5

5

115.01

114.52

98.98

98.93

22

16

50

70

2.5

5

5

173.03

172.42

97.5

97.15

23

38

50

30

7.5

5

5

171.95

173.25

97.1

96.90

24

43

50

70

7.5

5

5

176.67

177.18

97.87

98.02

25

31

25

50

5

4

5

175.01

174.57

97.21

97.03

26

35

75

50

5

4

5

183.12

183.25

98.32

98.60

27

3

25

50

5

6

5

243.01

242.46

99.01

99.09

28

44

75

50

5

6

5

200.1

200.02

98.22

98.07

29

42

50

50

2.5

5

4

163.02

163.04

97.11

97.15

30

36

50

50

7.5

5

4

179

178.49

97.66

97.66

31

24

50

50

2.5

5

6

117.91

118.45

97.47

97.69

32

28

50

50

7.5

5

6

180.1

179.32

97.32

97.43

33

21

25

50

5

5

4

244.13

243.77

96.11

96.59

34

45

75

50

5

5

4

181.71

182.42

98.3

98.12

35

12

25

50

5

5

6

225.91

226.17

98.1

97.94

36

27

75

50

5

5

6

179.63

179.81

97.55

97.32

37

40

50

30

5

4

5

184.01

183.73

97.76

97.30

38

46

50

70

5

4

5

195.21

195.26

98.05

97.74

39

17

50

30

5

6

5

193.89

193.94

97.43

97.48

40

32

50

70

5

6

5

177.58

177.66

97.43

97.32

41

6

50

50

5

5

5

194.42

194.78

97.96

97.97

42

4

50

50

5

5

5

156.55

156.97

97.16

97.22

43

15

50

50

5

5

5

184.67

184.56

97.42

97.66

44

18

50

50

5

5

5

237.99

238.53

97.66

96.76

45

14

50

50

5

5

5

222.23

222.25

95.01

95.61

46

30

50

50

5

5

5

166.66

166.96

98.87

98.32