Folic acid-functionalized PEGylated niosomes co-encapsulated cisplatin and doxoribicin exhibit enhanced anticancer efficacy

Table 2 Optimized responses obtained by Box–Behnken method and the experimental data for the same responses under the optimum conditions

Parameter	Predicted by Box–Behnken method	DOX–CIS-Nio	DOX–CIS-Nio@PEG–FA	Empty Niosome (Nio)
Average size (nm)	218.73	248.7 ± 7.37	214.6 ± 8.50	143.0 ± 5.47
PDI^a	0.246	0.214 ± 0.01	0.177 ± 0.009	0.201 ± 0.012
EE^b (DOX; %)	71.09	80.65 ± 1.80	83.29 ± 1.38	–
EE^b (CIS; %)	67.27	65.54 ± 1.25	72.73 ± 1.86	–

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