Folic acid-functionalized PEGylated niosomes co-encapsulated cisplatin and doxoribicin exhibit enhanced anticancer efficacy

Table 4 Kinetic release models and the parameters obtained for optimum niosomal formulation

Kinetic model	Zero-order		First-order	Higuchi	Korsmeyer–Peppas
	C_t = C₀ + K₀t		LogC = LogC0 + K_t/2.303	Q = K_H	M_t/M_ꝏ = K_t.tⁿ
	r²		r²	r²	r²	n^a
DOX (aq)	pH 7.4	0.4530	0.9167	0.6250	0.7474	0.4643
CIS (aq)	pH 7.4	0.4565	0.8475	0.6284	0.7702	0.4543
DOX–CIS-Nio
DOX	pH 7.4	0.7529	0.8159	0.8967	0.9163	0.6436
CIS	pH 7.4	0.8445	0.8987	0.9532	0.9522	0.6922
DOX–CIS-Nio@PEG–FA
DOX	pH 7.4	0.7701	0.8694	0.9089	0.9287	0.4951
CIS	pH 7.4	0.8445	0.8987	0.9532	0.9522	0.6922

Zero-order model: where C_t is the drug amount released in time t, C₀ is the initial drug amount in the solution and K₀ is the zero-order kinetic model constant
First-order model: where C₀ is the initial drug concentration, K_t is the rate constant, and t is the time
Higuchi model: Q is the drug amount released in time t, and K_H is the kinetic model constant
Korsmeyer-Peppa’s model: where M_t/M_ꝏ = K_t.tⁿ is a drug released fraction at time t, n is the release exponent, and K is the release rate constant
r²: The regression coefficient

ISSN: 1868-6966