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Fig. 5 | Cancer Nanotechnology

Fig. 5

From: Nanoparticle delivery of si-Notch1 modulates metabolic reprogramming to affect 5-FU resistance and cell pyroptosis in colorectal cancer

Fig. 5

Synthesis and cellular uptake of PLAG nanoparticles (NPs). A Sketch map showing synthesis of PLAG NPs and Notch1 siRNA loading. B The binding ability of PLAG NPs to Notch1 siRNA at different mass ratios was detected using agarose gel retardation electrophoresis. C Transmission electron microscope image showed the shape of the PLGA NPs. D Size distribution profiles of empty PLGA NPs and PLGA NPs containing Notch1 siRNA on DLS analysis. E In vitro release profile of siRNAs from siRNAs@PLAG NPs. F Confocal microscopic images of SW620-R and HCT8-R cells transfected with Notch1 siRNA using Lipofectamine 2000 or PLGA NPs. Green: fluorescein (FAM)-labeled siRNA; blue: Hoechst 33342-stained nuclei

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Cancer Nanotechnology

ISSN: 1868-6966

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