Fig. 12
From: Nanoparticles for MRI-guided radiation therapy: a review
(Reproduced with permission from Tse et al. (2015), copyright 2015, Future Medicine Ltd)
Systemic administration of antibody-conjugated SPIONs (J591-MNP) against PSMA in mice, compared to unconjugated SPIONs (MNP alone), measured on a T2 MRI scan. Injection was performed when tumour size (measured by bioluminescence, shown in the figure inserts) reached target values antibody-mediated uptake in the conjugated example enables greater total uptake in the tumour (red arrows)