Articles

A novel formulation of theranostic nanomedicine for targeting drug delivery to gastrointestinal tract cancer

Theranostic nanomedicines contain a nanovehicle that has fluorescent properties and can be used for diagnostic, therapeutic and prognostic purposes. The transferrin receptor expression is 1000-fold higher in r...

Authors: Madeeha Shahzad Lodhi, Muhammad Tahir Khan, Saira Aftab, Zahoor Qadir Samra, Heng Wang and Dong Qing Wei

Novel nanoformulation of disulfiram with bacterially synthesized copper oxide nanoparticles for augmenting anticancer activity: an in vitro study

Disulfiram (DS), in the presence of copper (Cu), exhibited potent broad anticancer activity. However, its clinical application is limited due to the poor solubility and stability. Hence, a novel nanocombinatio...

Authors: Marwa M. Abu‑Serie and Marwa Eltarahony

Antitumor efficiency of the natural alkaloid berberine complexed with C₆₀ fullerene in Lewis lung carcinoma in vitro and in vivo

Berberine (Ber) is a herbal alkaloid with pharmacological activity in general and a high anticancer potency in particular. However, due to its low bioavailability, the difficulty in reaching a target and choos...

Authors: Anna Grebinyk, Svitlana Prylutska, Sergii Grebinyk, Maxim Evstigneev, Iryna Krysiuk, Tetiana Skaterna, Iryna Horak, Yanfang Sun, Liudmyla Drobot, Olga Matyshevska, Yuriy Prylutskyy, Uwe Ritter and Marcus Frohme

Montmorillonite colloid plates with adsorbed cytochrome c: in vitro cytotoxic effect on colon cancer cell culture

The apoptosis (a cascade of biochemical reactions leading to suicide of damaged biological cells) is blocked in the cancer cells because of impossibility of cytochrome c (cytC) go out from the mitochondria. Howev...

Authors: Svetlana H. Hristova and Alexandar M. Zhivkov

Emodin-loaded polymer-lipid hybrid nanoparticles enhance the sensitivity of breast cancer to doxorubicin by inhibiting epithelial–mesenchymal transition

The role of epithelial–mesenchymal transition (EMT) involved in breast cancer metastasis and chemoresistance has been increasingly recognized. However, it is necessary to search for more effective strategies t...

Authors: Tengteng Zou, Meng Lan, Fengjie Liu, Lihong Li, Tiange Cai, Huaqin Tian and Yu Cai

Nanoparticles derived from insect exoskeleton modulates NLRP3 inflammasome complex activation in cervical cancer cell line model

Immune evasion is an important hallmark of cancer progression and tumourigenesis. Among the cancer types, cervical cancer has very high global prevalence, severely affecting female reproductive health. Its pre...

Authors: Rituparna Chakraborty, Ujjal Bose, Goutam Pawaskar, Satish Rao Bola Sadashiva and Ritu Raval

Synthesis of gold nanorods and their performance in the field of cancer cell imaging and photothermal therapy

Cancer is one of the most common incident in the world, with malignant tumors having a death rate of up to 19%. A new method of treating cancer cells effectively with minimal cytotoxicity is needed. In the fie...

Authors: Naseer Ullah Khan, Jing Lin, Muhammad Rizwan Younas, Xukun Liu and Liming Shen

Comparative effect of thermo/pH-responsive polymer-coated gold nanocages and hollow nanostars on chemo-photothermal therapy of breast cancer cells

Combination chemo-photothermal therapy appears to be one of the next generations of cancer treatment. In this study hollow gold nanostars (HGNSs) and gold nanocages (GNCs) were synthesized and stabilized with ...

Authors: Asrin Pakravan, Mehdi Azizi, Fariborz Rahimi, Farhad Bani, Farideh Mahmoudzadeh, Roya Salehi and Mehrdad Mahkam

Recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment

In the last decade, graphene oxide-based nanomaterials, such as graphene oxide (GO) and reduced graphene oxide (rGO), have attracted more and more attention in the field of biomedicine. Due to the versatile su...

Authors: Lijun Liu, Qingming Ma, Jie Cao, Yang Gao, Shangcong Han, Yan Liang, Tingting Zhang, Yang Song and Yong Sun

Ultrasound-activated nano-TiO₂ loaded with temozolomide paves the way for resection of chemoresistant glioblastoma multiforme

Glioblastoma multiforme (GBM) is one of the most daunting issues to modern therapeutics, with a higher mortality rate post-diagnosis. Temozolomide (TMZ) is the only available treatment; however, the frequent r...

Authors: Fawad Ur Rehman, Mohd Ahmar Rauf, Sajjad Ullah, Sana Shaikh, Aqsa Qambrani, Pir Muhammad and Sumaira Hanif

Radiolabeling and PET–MRI microdosing of the experimental cancer therapeutic, MN-anti-miR10b, demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer

In our earlier work, we identified microRNA-10b (miR10b) as a master regulator of the viability of metastatic tumor cells. This knowledge allowed us to design a miR10b-targeted therapeutic consisting of an ant...

Authors: Mariane Le Fur, Alana Ross, Pamela Pantazopoulos, Nicholas Rotile, Iris Zhou, Peter Caravan, Zdravka Medarova and Byunghee Yoo

Breast cancer drug delivery by novel drug-loaded chitosan-coated magnetic nanoparticles

Breast cancer is one of the most challenging cancers among women which is considered one of the most lethal cancers to this date. From the time that cancer has been discovered, finding the best therapeutic met...

Authors: A. Taherian, N. Esfandiari and S. Rouhani

Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect

Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer ...

Authors: Farnaz Dabbagh Moghaddam, Iman Akbarzadeh, Ehsan Marzbankia, Mahsa Farid, Leila khaledi, Amir Hossein Reihani, Mehrnoosh Javidfar and Pejman Mortazavi

Lipid polymeric nanoparticles modified with tight junction-modulating peptides promote afatinib delivery across a blood–brain barrier model

Brain metastases from non-small cell lung cancer (NSCLC) remain one of the most challenging malignancies. Afatinib (Afa) is an orally administered irreversible ErbB family blocker approved for epidermal growth...

Authors: Yu-Li Lo, Hua-Ching Lin, Shu-Ting Hong, Chih-Hsien Chang, Chen-Shen Wang and Anya Maan-Yuh Lin

Development of Fe₃O₄ core–TiO₂ shell nanocomposites and nanoconjugates as a foundation for neuroblastoma radiosensitization

Neuroblastoma is the most common extracranial solid malignancy in childhood which, despite the current progress in radiotherapy and chemotherapy protocols, still has a high mortality rate in high risk tumors. ...

Authors: William Liu, Salida Mirzoeva, Ye Yuan, Junjing Deng, Si Chen, Barry Lai, Stefan Vogt, Karna Shah, Rahul Shroff, Reiner Bleher, Qiaoling Jin, Nghia Vo, Remon Bazak, Carissa Ritner, Stanley Gutionov, Sumita Raha…

Methylene blue associated with maghemite nanoparticles has antitumor activity in breast and ovarian carcinoma cell lines

Cancer constitutes group of diseases responsible for the second largest cause of global death, and it is currently considered one of the main public health concerns nowadays. Early diagnosis associated with th...

Authors: Ana Luísa G. Silva, Natália V. Carvalho, Leonardo G. Paterno, Ludmilla D. Moura, Cleber L. Filomeno, Eneida de Paula and Sônia N. Báo

Ultrasensitive bioassaying of HER-2 protein for diagnosis of breast cancer using reduced graphene oxide/chitosan as nanobiocompatible platform

In this label-free bioassay, an electrochemiluminescence (ECL) immunosensor was developed for the quantification of breast cancer using HER-2 protein as a metastatic biomarker.

Authors: Hassan Nasrollahpour, Ibrahim Isildak, Mohammad-Reza Rashidi, Esmat Alsadat Hashemi, Abdolhosein Naseri and Balal Khalilzadeh

Correction to: Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells

An amendment to this paper has been published and can be accessed via the original article.

Authors: Monika Ruzycka-Ayoush, Patrycja Kowalik, Agata Kowalczyk, Piotr Bujak, Anna M. Nowicka, Maria Wojewodzka, Marcin Kruszewski and Ireneusz P. Grudzinski

Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells

Lung cancer is one of the most frequently diagnosed cancers all over the world and is also one of the leading causes of cancer-related mortality. The main treatment option for small cell lung cancer, conventio...

Authors: Monika Ruzycka-Ayoush, Patrycja Kowalik, Agata Kowalczyk, Piotr Bujak, Anna M. Nowicka, Maria Wojewodzka, Marcin Kruszewski and Ireneusz P. Grudzinski

Investigating the effect of outer layer of magnetic particles on cervical cancer cells HeLa by magnetic fluid hyperthermia

Magnetic fluid hyperthermia (MFH) is a successful nanotechnology application in recent decade where a biocompatible magnetic fluid is used to kill cancer cells in a controlled heating using AC magnetic field. ...

Authors: Anand Bhardwaj, Neeraj Jain and Kinnari Parekh

Non-invasive transdermal delivery of chemotherapeutic molecules in vivo using superparamagnetic iron oxide nanoparticles

The skin is both a target and a potential conduit for the delivery of drugs, but its cornified cell layer resists penetration by most molecules. This study investigated the potential of superparamagnetic iron ...

Authors: Vanisri Raviraj, Binh T. T. Pham, Byung J. Kim, Nguyen T. H. Pham, Lai F. Kok, Nicole Painter, Naomi C. Delic, Stephen K. Jones, Brian S. Hawkett and J. Guy Lyons

Targeting BMI-1 with PLGA–PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells

Despite advances in glioblastoma (GBM) treatments, current approaches have failed to improve the overall survival of patients. The oncogene BMI-1, a core member of the polycomb group proteins, is a potential n...

Authors: Elham Poonaki, Fatemeh Ariakia, Mohammad Jalili-Nik, Mehdi Shafiee Ardestani, Gholamhossein Tondro, Fariborz Samini, Sepideh Ghasemi, Sajad Sahab-Negah and Ali Gorji

Excretable, ultrasmall hexagonal NaGdF₄:Yb50% nanoparticles for bimodal imaging and radiosensitization

In this study, we report on the synthesis, imaging, and radiosensitizing properties of ultrasmall β-NaGdF₄:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as poten...

Authors: Jossana A. Damasco, Tymish Y. Ohulchanskyy, Supriya Mahajan, Guanying Chen, Ajay Singh, Hilliard L. Kutscher, Haoyuan Huang, Steven G. Turowski, Joseph A. Spernyak, Anurag K. Singh, Jonathan F. Lovell, Mukund Seshadri and Paras N. Prasad

Curcumin-enriched Gemini surfactant nanoparticles exhibited tumoricidal effects on human 3D spheroid HT-29 cells in vitro

Here, we examined the tumoricidal effect of Gemini surfactant nanoparticles enriched with curcumin on 3D spheroid HT-29 cells. The delivery of curcumin and other phytocompounds to the tumor niche is an importa...

Authors: Zohre Zibaei, Esmaeil Babaei, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi and Hewa Jalal Azeez

Graphene oxide nanofilm and chicken embryo extract decrease the invasiveness of HepG2 liver cancer cells

The extracellular matrix (ECM) is a mosaic of various structural and functional proteins that cooperate with the cell, regulate adhesion, and consequently manage its further fate. Liver destruction is accompan...

Authors: Malwina Sosnowska, Marta Kutwin, Barbara Strojny, Piotr Koczoń, Jarosław Szczepaniak, Jaśmina Bałaban, Karolina Daniluk, Sławomir Jaworski, André Chwalibog, Wiesław Bielawski and Ewa Sawosz

Experimental conditions influence the formation and composition of the corona around gold nanoparticles

Ovarian cancer is one of the deadliest gynecological malignancies. While the overall survival of ovarian cancer patients has slightly improved in recent years in the developed world, it remains clinically chal...

Authors: Md. Nazir Hossen, Chandra Kumar Elechalawar, Virginie Sjoelund, Kathleen Moore, Robert Mannel, Resham Bhattacharya and Priyabrata Mukherjee

Nanomedicine-mediated induction of immunogenic cell death and prevention of PD-L1 overexpression for enhanced hepatocellular carcinoma therapy

The present study aims to develop a nanoparticle encapsulating doxorubicin (DOX) and programmed death-ligand 1 (PD-L1) siRNA and evaluate its anti-tumor effects on hepatoma carcinoma (HCC).

Authors: Hanzhang Zhu, Weijiang Zhou, Yafeng Wan, Ke Ge, Jun Lu and Changku Jia

Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro

Amphiphilic block copolymers used as nanomicelle drug carriers can effectively overcome poor drug solubility and specificity issues. Hence, these platforms have a broad applicability in cancer treatment. In th...

Authors: S. Pisano, X. Wang, J. Garcia-Parra, A. Gazze, K. Edwards, V. Feltracco, Y. Hu, L. He, D. Gonzalez, L. W. Francis, R. S. Conlan and C. Li

Synthesis and analysis of silver–copper alloy nanoparticles of different ratios manifest anticancer activity in breast cancer cells

Breast cancer is therapeutically very challenging to treat as it has the main four known genetic alterations, which result in the existence of several phenotypes leading to the difference in the mode of therap...

Authors: Sara Al Tamimi, Sarmadia Ashraf, Tahir Abdulrehman, Aijaz Parray, Said A. Mansour, Yousef Haik and Shahnaz Qadri

Nanotechnology approaches to addressing HER2-positive breast cancer

Breast cancer is a major cause of cancer-associated deaths in the United States. It was estimated that 12% of women in the U.S. will develop invasive breast cancer in their lifetime. The human epidermal growth...

Authors: Bryan E. White, Molly K. White, Het Adhvaryu, Issam Makhoul, Zeid A. Nima, Alexandru S. Biris and Nawab Ali

Algae-meditated route to cuprous oxide (Cu₂O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer

Breast cancer (BC), as the most widely recognized disease in women worldwide, represents about 30% of all cancers impacting women. This study was aimed to synthesize Cu₂O nanoparticles from the cystoseira myrica ...

Authors: Parisa Taherzadeh-Soureshjani and Mohammad Chehelgerdi

Cockle shell-derived aragonite calcium carbonate nanoparticle for targeting cancer and breast cancer stem cells

Cockle shell-derived aragonite calcium carbonate nanoparticles (CACNP) have demonstrated prospect as nano-sized drug carriers for targeting cancer cells. CACNP is biocompatible, biodegradable and its biomateri...

Authors: Kehinde Muibat Ibiyeye, Sherifat Banke Idris and Abu Bakar Zakaria Zuki

Enhanced MRI-guided radiotherapy with gadolinium-based nanoparticles: preclinical evaluation with an MRI-linac

The AGuIX^® (NH TherAguix) nanoparticle has been developed to enhance radiotherapy treatment and provide strong MR contrast. These two properties have previously been investigated separately and progressed to clin...

Authors: H. L. Byrne, G. Le Duc, F. Lux, O. Tillement, N. M. Holmes, A. James, U. Jelen, B. Dong, G. Liney, T. L. Roberts and Z. Kuncic

Elucidating the fate of nanoparticles among key cell components of the tumor microenvironment for promoting cancer nanotechnology

Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components...

Authors: Kyle Bromma, Aaron Bannister, Antonia Kowalewski, Leah Cicon and Devika B. Chithrani

Cancer research, treatment, and COVID-19

Authors: Steven A. Curley, Frederick Currell, Sunil Krishnan and Zeljka Krpetic

Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy

Doxorubicin-loaded hollow gold nanospheres (Dox@HAuNS) are a promising technology for simultaneous trans-arterial tumor-targeted chemotherapy delivery and thermal ablation. We evaluated the efficacy of intra-a...

Authors: Rahul A. Sheth, Xiaoxia Wen, Junjie Li, Marites P. Melancon, Xin Ji, Y. Andrew Wang, Cheng-Hui Hsiao, Diana S.-L. Chow, Elizabeth M. Whitley, Chun Li and Sanjay Gupta

Comparative study on contrast enhancement of Magnevist and Magnevist-loaded nanoparticles in pancreatic cancer PDX model monitored by MRI

The aim of this study was to compare contrast enhancement of Magnevist^® (gadopentate dimeglumine (Mag)) to that of PEGylated Magnevist^®-loaded liposomal nanoparticles (Mag-Lnps) in pancreatic cancer patient-deriv...

Authors: Kevin Affram, Taylor Smith, Shannon Helsper, Jens T. Rosenberg, Bo Han, Jose Trevino and Edward Agyare

Reducing the effective dose of cisplatin using gold nanoparticles as carriers

Nanotechnology is a frequent treatment for cancer. Nanomaterials are the vehicles which deliver drugs in smaller but equally effective quantities. The aim of this investigation is to synthesize gold nanopartic...

Authors: M. A. González-López, E. M. Gutiérrez-Cárdenas, C. Sánchez-Cruz, J. F. Hernández-Paz, I. Pérez, J. J. Olivares-Trejo and O. Hernández-González

Preferential drug delivery to tumor cells than normal cells using a tunable niosome–chitosan double package nanodelivery system: a novel in vitro model

We previously described the properties of a targeted drug delivery system (DDS) in a cell-free system. Here, in this comparative cell-based study (normal and tumor cells), we provide a quantitative analysis of...

Authors: Marzenna Wiranowska, Rupin Singh, Rana Falahat, Eva Williams, Joseph O. Johnson and Norma Alcantar

A [60]fullerene nanoconjugate with gemcitabine: synthesis, biophysical properties and biological evaluation for treating pancreatic cancer

The first-line chemotherapy drug that is used to treat pancreatic ductal adenocarcinoma is gemcitabine. Unfortunately, its effectiveness is hampered by its chemo-resistance, low vascularization and drug biodis...

Authors: Paweł Nalepa, Robert Gawecki, Grzegorz Szewczyk, Katarzyna Balin, Mateusz Dulski, Mieczysław Sajewicz, Anna Mrozek-Wilczkiewicz, Robert Musioł, Jaroslaw Polanski and Maciej Serda

Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications

Fluorescent silica nanoparticles have been extensively utilised in a broad range of biological applications and are facilitated by their predictable, well-understood, flexible chemistry and apparent biocompati...

Authors: Vladimir Gubala, Giorgia Giovannini, Filip Kunc, Marco P. Monopoli and Colin J. Moore

Nanomedicine review: clinical developments in liposomal applications

In recent years, disease treatment has evolved strategies that require increase in pharmaceutical agent’s efficacy and selectivity while decreasing their toxicity in normal tissues. These requirements have led...

Authors: Esteban Beltrán-Gracia, Adolfo López-Camacho, Inocencio Higuera-Ciapara, Jesús B Velázquez-Fernández and Alba A Vallejo-Cardona

A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays

A wide range of nanoparticles (NPs), composed of different elements and their compounds, are being developed by several groups as possible radiosensitisers, with some already in clinical trials. However, no sy...

Authors: Alexandra Guerreiro, Nicholas Chatterton, Eleanor M. Crabb and Jon P. Golding

Science vs. technology in radiation therapy from X-rays to ions

Authors: Eugene Surdutovich and Andrey V Solov’yov

Effects and side effects of plasmonic photothermal therapy in brain tissue

Heat generated from plasmonic nanoparticles can be utilized in plasmonic photothermal therapy. A combination of near-infrared laser and plasmonic nanoparticles is compelling for the treatment of brain cancer, ...

Authors: Yue He, Kristoffer Laugesen, Dana Kamp, Salik A. Sultan, Lene B. Oddershede and Liselotte Jauffred

Comparison of the effect of rhodium citrate-associated iron oxide nanoparticles on metastatic and non-metastatic breast cancer cells

Nanocarriers have the potential to improve the therapeutic index of currently available drugs by increasing drug efficacy, lowering drug toxicity and achieving steady-state therapeutic levels of drugs over an ...

Authors: Natalia Lemos Chaves, Danilo Aquino Amorim, Cláudio Afonso Pinho Lopes, Irina Estrela-Lopis, Julia Böttner, Aparecido Ribeiro de Souza and Sônia Nair Báo

Multiscale modeling for cancer radiotherapies

Ion-beam cancer therapy, an alternative to a common radiation therapy with X-rays, has been used clinically around the world since 1990s; the number of proton therapy centers as well as facilities using heavie...

Authors: Eugene Surdutovich and Andrey V. Solov’yov

The role of shock waves on the biodamage induced by ion beam radiation

Energetic ions irradiate the human body in different situations such as exposure to galactic cosmic rays and ion beam cancer therapy. Ions propagating through dense medium deposit energy on the nanometre scale...

Authors: Pablo de Vera, Eugene Surdutovich and Andrey V. Solov’yov

Phenomenon-based evaluation of relative biological effectiveness of ion beams by means of the multiscale approach

Relative biological effectiveness (RBE) is a key quantity for the description of radiobiological effects induced by charged-particle irradiation in the context of ion-beam cancer therapy. Since RBE is a comple...

Authors: Alexey Verkhovtsev, Eugene Surdutovich and Andrey V. Solov’yov

Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O₂ and radiosensitization by nanoparticles

This article reviews radiation chemistry processes induced by high-linear energy transfer (LET) radiation. The first part gives a short historical introduction and defines the essential concepts of radiation c...

Authors: Gérard Baldacchino, Emilie Brun, Ibtihel Denden, Sarah Bouhadoun, Raphael Roux, Hicham Khodja and Cécile Sicard-Roselli