Articles

Baicalin-loaded folic acid-modified albumin nanoparticles (FA-BSANPs/BA) induce autophagy in MCF-7 cells via ROS-mediated p38 MAPK and Akt/mTOR pathway

Breast cancer is the most frequently occurring cancer among women. Baicalin has been shown to inhibit breast cancer proliferation, but poor aqueous solubility and unknown mechanism of action limit its applicat...

Authors: Fengjie Liu, Meng Lan, Baoqi Ren, Lihong Li, Tengteng Zou, Zhaodi Kong, Dongmei Fan, Tiange Cai and Yu Cai

Non-homogeneous dispersion of graphene in polyacrylonitrile substrates induces a migrastatic response and epithelial-like differentiation in MCF7 breast cancer cells

Recent advances from studies of graphene and graphene-based derivatives have highlighted the great potential of these nanomaterials as migrastatic agents with the ability to modulate tumor microenvironments. N...

Authors: Nazely Diban, Marián Mantecón-Oria, María T. Berciano, Alba Puente-Bedia, María J. Rivero, Ane Urtiaga, Miguel Lafarga and Olga Tapia

Potential anti-tumor activity of 13.56 MHz alternating magnetic hyperthermia and chemotherapy on the induction of apoptosis in human colon cancer cell lines HT29 and HCT116 by up-regulation of Bax, cleaved caspase 3&9, and cleaved PARP proteins

The purpose of the present study was to evaluate the efficacy of chemo-magnetic hyperthermia (MH), a combination of alternating magnetic field (AMF) and superparamagnetic nanoparticles (SPIONs) coated with Pol...

Authors: Saba Jahangiri, Samideh Khoei, Sepideh Khoee, Majid Safa, Sakine Shirvalilou and Vahid Pirhajati Mahabadi

Synergistic action of curcumin and cisplatin on spinel ferrite/hierarchical MCM-41 nanocomposite against MCF-7, HeLa and HCT 116 cancer cell line

Platinum-based drugs are widely used in cancer therapy, but are known for toxic side effects and resistance. Combinational drug delivery represents an effective chemotherapeutic strategy, but often leads to an...

Authors: B. Rabindran Jermy, D. Almohazey, W. A. Alamoudi, R. M. Palanivel, Nora AlSudairi, H. Dafalla, A. A. Almofleh, T. M. Alfareed and Vijaya Ravinayagam

A combined miR-34a and arsenic trioxide nanodrug delivery system for synergistic inhibition of HCC progression after microwave ablation

Microwave ablation (MWA) has become an alternative treatment for unresectable hepatocellular carcinoma (HCC), but it does not eliminate the risk of recurrence and metastasis after treatment. Recent studies hav...

Authors: Jian Hu, Wenceng Pei, Zhenyou Jiang and Zihuang Li

Synergistic effect of folate-conjugated polymers and 5-fluorouracil in the treatment of colon cancer

In recent years, targeted drug delivery strategies have received special attention from the scientific world due to advantages such as more effective therapy and reduction of side effects. The principle of ope...

Authors: Gabriela Siemiaszko, Katarzyna Niemirowicz-Laskowska, Karolina H. Markiewicz, Iwona Misztalewska-Turkowicz, Ewelina Dudź, Sylwia Milewska, Paweł Misiak, Izabela Kurowska, Anna Sadowska, Halina Car and Agnieszka Z. Wilczewska

Promising self-emulsifying drug delivery system loaded with lycopene from red guava (Psidium guajava L.): in vivo toxicity, biodistribution and cytotoxicity on DU-145 prostate cancer cells

Self-emulsifying drug delivery systems (SEDDSs) have attracted attention because of their effects on solubility and bioavailability of lipophilic compounds. Herein, a SEDDS loaded with lycopene purified from r...

Authors: Andreanne G. Vasconcelos, Ana Luisa A. N. Barros, Wanessa F. Cabral, Daniel C. Moreira, Ingrid Gracielle M. da Silva, Amandda É. Silva-Carvalho, Miguel P. de Almeida, Lucas F. F. Albuquerque, Raimunda C. dos Santos, Ana Karolinne S. Brito, Felipe Saldanha-Araújo, Daniel D. R. Arcanjo, Maria do Carmo C. Martins, Tatiana K. dos S. Borges, Sônia N. Báo, Alexandra Plácido…

Preparation of nanoparticles of β-cyclodextrin-loaded scutellarein anti-tumor activity research by targeting integrin α_vβ3

The problems associated with the poor water solubility of anticancer drugs are one of the most important challenges in achieving effective cancer therapy. The present study was designed to evaluate the effect ...

Authors: Jundong Wang, Tianhao Li, Chaochi Yue, Sen Zhong, Xiangdong Yang, Jun Li and Yuanzhi Li

Cytotoxic, apoptotic, and genetic evaluations of Nigella sativa essential oil nanoemulsion against human hepatocellular carcinoma cell lines

Phytochemicals and plant extracts are showing promising anticancer potentials. In the current study, the volatile faction (essential oil) of Nigella sativa seeds was evaluated against some hepatocellular carcinom...

Authors: Ahmed A. Abd-Rabou and Amr E. Edris

Multi-scale Monte Carlo simulations of gold nanoparticle-induced DNA damages for kilovoltage X-ray irradiation in a xenograft mouse model using TOPAS-nBio

Gold nanoparticles (AuNPs) are considered as promising agents to increase the radiosensitivity of tumor cells. However, the biological mechanisms of radiation enhancement effects of AuNPs are still not well un...

Authors: Alexander P. Klapproth, Jan Schuemann, Stefan Stangl, Tianwu Xie, Wei Bo Li and Gabriele Multhoff

A novel formulation of theranostic nanomedicine for targeting drug delivery to gastrointestinal tract cancer

Theranostic nanomedicines contain a nanovehicle that has fluorescent properties and can be used for diagnostic, therapeutic and prognostic purposes. The transferrin receptor expression is 1000-fold higher in r...

Authors: Madeeha Shahzad Lodhi, Muhammad Tahir Khan, Saira Aftab, Zahoor Qadir Samra, Heng Wang and Dong Qing Wei

Novel nanoformulation of disulfiram with bacterially synthesized copper oxide nanoparticles for augmenting anticancer activity: an in vitro study

Disulfiram (DS), in the presence of copper (Cu), exhibited potent broad anticancer activity. However, its clinical application is limited due to the poor solubility and stability. Hence, a novel nanocombinatio...

Authors: Marwa M. Abu‑Serie and Marwa Eltarahony

Antitumor efficiency of the natural alkaloid berberine complexed with C₆₀ fullerene in Lewis lung carcinoma in vitro and in vivo

Berberine (Ber) is a herbal alkaloid with pharmacological activity in general and a high anticancer potency in particular. However, due to its low bioavailability, the difficulty in reaching a target and choos...

Authors: Anna Grebinyk, Svitlana Prylutska, Sergii Grebinyk, Maxim Evstigneev, Iryna Krysiuk, Tetiana Skaterna, Iryna Horak, Yanfang Sun, Liudmyla Drobot, Olga Matyshevska, Yuriy Prylutskyy, Uwe Ritter and Marcus Frohme

Montmorillonite colloid plates with adsorbed cytochrome c: in vitro cytotoxic effect on colon cancer cell culture

The apoptosis (a cascade of biochemical reactions leading to suicide of damaged biological cells) is blocked in the cancer cells because of impossibility of cytochrome c (cytC) go out from the mitochondria. Howev...

Authors: Svetlana H. Hristova and Alexandar M. Zhivkov

Emodin-loaded polymer-lipid hybrid nanoparticles enhance the sensitivity of breast cancer to doxorubicin by inhibiting epithelial–mesenchymal transition

The role of epithelial–mesenchymal transition (EMT) involved in breast cancer metastasis and chemoresistance has been increasingly recognized. However, it is necessary to search for more effective strategies t...

Authors: Tengteng Zou, Meng Lan, Fengjie Liu, Lihong Li, Tiange Cai, Huaqin Tian and Yu Cai

Nanoparticles derived from insect exoskeleton modulates NLRP3 inflammasome complex activation in cervical cancer cell line model

Immune evasion is an important hallmark of cancer progression and tumourigenesis. Among the cancer types, cervical cancer has very high global prevalence, severely affecting female reproductive health. Its pre...

Authors: Rituparna Chakraborty, Ujjal Bose, Goutam Pawaskar, Satish Rao Bola Sadashiva and Ritu Raval

Synthesis of gold nanorods and their performance in the field of cancer cell imaging and photothermal therapy

Cancer is one of the most common incident in the world, with malignant tumors having a death rate of up to 19%. A new method of treating cancer cells effectively with minimal cytotoxicity is needed. In the fie...

Authors: Naseer Ullah Khan, Jing Lin, Muhammad Rizwan Younas, Xukun Liu and Liming Shen

Comparative effect of thermo/pH-responsive polymer-coated gold nanocages and hollow nanostars on chemo-photothermal therapy of breast cancer cells

Combination chemo-photothermal therapy appears to be one of the next generations of cancer treatment. In this study hollow gold nanostars (HGNSs) and gold nanocages (GNCs) were synthesized and stabilized with ...

Authors: Asrin Pakravan, Mehdi Azizi, Fariborz Rahimi, Farhad Bani, Farideh Mahmoudzadeh, Roya Salehi and Mehrdad Mahkam

Recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment

In the last decade, graphene oxide-based nanomaterials, such as graphene oxide (GO) and reduced graphene oxide (rGO), have attracted more and more attention in the field of biomedicine. Due to the versatile su...

Authors: Lijun Liu, Qingming Ma, Jie Cao, Yang Gao, Shangcong Han, Yan Liang, Tingting Zhang, Yang Song and Yong Sun

Ultrasound-activated nano-TiO₂ loaded with temozolomide paves the way for resection of chemoresistant glioblastoma multiforme

Glioblastoma multiforme (GBM) is one of the most daunting issues to modern therapeutics, with a higher mortality rate post-diagnosis. Temozolomide (TMZ) is the only available treatment; however, the frequent r...

Authors: Fawad Ur Rehman, Mohd Ahmar Rauf, Sajjad Ullah, Sana Shaikh, Aqsa Qambrani, Pir Muhammad and Sumaira Hanif

Radiolabeling and PET–MRI microdosing of the experimental cancer therapeutic, MN-anti-miR10b, demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer

In our earlier work, we identified microRNA-10b (miR10b) as a master regulator of the viability of metastatic tumor cells. This knowledge allowed us to design a miR10b-targeted therapeutic consisting of an ant...

Authors: Mariane Le Fur, Alana Ross, Pamela Pantazopoulos, Nicholas Rotile, Iris Zhou, Peter Caravan, Zdravka Medarova and Byunghee Yoo

Breast cancer drug delivery by novel drug-loaded chitosan-coated magnetic nanoparticles

Breast cancer is one of the most challenging cancers among women which is considered one of the most lethal cancers to this date. From the time that cancer has been discovered, finding the best therapeutic met...

Authors: A. Taherian, N. Esfandiari and S. Rouhani

Delivery of melittin-loaded niosomes for breast cancer treatment: an in vitro and in vivo evaluation of anti-cancer effect

Melittin, a peptide component of honey bee venom, is an appealing candidate for cancer therapy. In the current study, melittin, melittin-loaded niosome, and empty niosome had been optimized and the anticancer ...

Authors: Farnaz Dabbagh Moghaddam, Iman Akbarzadeh, Ehsan Marzbankia, Mahsa Farid, Leila khaledi, Amir Hossein Reihani, Mehrnoosh Javidfar and Pejman Mortazavi

Lipid polymeric nanoparticles modified with tight junction-modulating peptides promote afatinib delivery across a blood–brain barrier model

Brain metastases from non-small cell lung cancer (NSCLC) remain one of the most challenging malignancies. Afatinib (Afa) is an orally administered irreversible ErbB family blocker approved for epidermal growth...

Authors: Yu-Li Lo, Hua-Ching Lin, Shu-Ting Hong, Chih-Hsien Chang, Chen-Shen Wang and Anya Maan-Yuh Lin

Development of Fe₃O₄ core–TiO₂ shell nanocomposites and nanoconjugates as a foundation for neuroblastoma radiosensitization

Neuroblastoma is the most common extracranial solid malignancy in childhood which, despite the current progress in radiotherapy and chemotherapy protocols, still has a high mortality rate in high risk tumors. ...

Authors: William Liu, Salida Mirzoeva, Ye Yuan, Junjing Deng, Si Chen, Barry Lai, Stefan Vogt, Karna Shah, Rahul Shroff, Reiner Bleher, Qiaoling Jin, Nghia Vo, Remon Bazak, Carissa Ritner, Stanley Gutionov, Sumita Raha…

Methylene blue associated with maghemite nanoparticles has antitumor activity in breast and ovarian carcinoma cell lines

Cancer constitutes group of diseases responsible for the second largest cause of global death, and it is currently considered one of the main public health concerns nowadays. Early diagnosis associated with th...

Authors: Ana Luísa G. Silva, Natália V. Carvalho, Leonardo G. Paterno, Ludmilla D. Moura, Cleber L. Filomeno, Eneida de Paula and Sônia N. Báo

Ultrasensitive bioassaying of HER-2 protein for diagnosis of breast cancer using reduced graphene oxide/chitosan as nanobiocompatible platform

In this label-free bioassay, an electrochemiluminescence (ECL) immunosensor was developed for the quantification of breast cancer using HER-2 protein as a metastatic biomarker.

Authors: Hassan Nasrollahpour, Ibrahim Isildak, Mohammad-Reza Rashidi, Esmat Alsadat Hashemi, Abdolhosein Naseri and Balal Khalilzadeh

Correction to: Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells

An amendment to this paper has been published and can be accessed via the original article.

Authors: Monika Ruzycka-Ayoush, Patrycja Kowalik, Agata Kowalczyk, Piotr Bujak, Anna M. Nowicka, Maria Wojewodzka, Marcin Kruszewski and Ireneusz P. Grudzinski

Quantum dots as targeted doxorubicin drug delivery nanosystems in human lung cancer cells

Lung cancer is one of the most frequently diagnosed cancers all over the world and is also one of the leading causes of cancer-related mortality. The main treatment option for small cell lung cancer, conventio...

Authors: Monika Ruzycka-Ayoush, Patrycja Kowalik, Agata Kowalczyk, Piotr Bujak, Anna M. Nowicka, Maria Wojewodzka, Marcin Kruszewski and Ireneusz P. Grudzinski

Investigating the effect of outer layer of magnetic particles on cervical cancer cells HeLa by magnetic fluid hyperthermia

Magnetic fluid hyperthermia (MFH) is a successful nanotechnology application in recent decade where a biocompatible magnetic fluid is used to kill cancer cells in a controlled heating using AC magnetic field. ...

Authors: Anand Bhardwaj, Neeraj Jain and Kinnari Parekh

Non-invasive transdermal delivery of chemotherapeutic molecules in vivo using superparamagnetic iron oxide nanoparticles

The skin is both a target and a potential conduit for the delivery of drugs, but its cornified cell layer resists penetration by most molecules. This study investigated the potential of superparamagnetic iron ...

Authors: Vanisri Raviraj, Binh T. T. Pham, Byung J. Kim, Nguyen T. H. Pham, Lai F. Kok, Nicole Painter, Naomi C. Delic, Stephen K. Jones, Brian S. Hawkett and J. Guy Lyons

Targeting BMI-1 with PLGA–PEG nanoparticle-containing PTC209 modulates the behavior of human glioblastoma stem cells and cancer cells

Despite advances in glioblastoma (GBM) treatments, current approaches have failed to improve the overall survival of patients. The oncogene BMI-1, a core member of the polycomb group proteins, is a potential n...

Authors: Elham Poonaki, Fatemeh Ariakia, Mohammad Jalili-Nik, Mehdi Shafiee Ardestani, Gholamhossein Tondro, Fariborz Samini, Sepideh Ghasemi, Sajad Sahab-Negah and Ali Gorji

Excretable, ultrasmall hexagonal NaGdF₄:Yb50% nanoparticles for bimodal imaging and radiosensitization

In this study, we report on the synthesis, imaging, and radiosensitizing properties of ultrasmall β-NaGdF₄:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as poten...

Authors: Jossana A. Damasco, Tymish Y. Ohulchanskyy, Supriya Mahajan, Guanying Chen, Ajay Singh, Hilliard L. Kutscher, Haoyuan Huang, Steven G. Turowski, Joseph A. Spernyak, Anurag K. Singh, Jonathan F. Lovell, Mukund Seshadri and Paras N. Prasad

Curcumin-enriched Gemini surfactant nanoparticles exhibited tumoricidal effects on human 3D spheroid HT-29 cells in vitro

Here, we examined the tumoricidal effect of Gemini surfactant nanoparticles enriched with curcumin on 3D spheroid HT-29 cells. The delivery of curcumin and other phytocompounds to the tumor niche is an importa...

Authors: Zohre Zibaei, Esmaeil Babaei, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi and Hewa Jalal Azeez

Graphene oxide nanofilm and chicken embryo extract decrease the invasiveness of HepG2 liver cancer cells

The extracellular matrix (ECM) is a mosaic of various structural and functional proteins that cooperate with the cell, regulate adhesion, and consequently manage its further fate. Liver destruction is accompan...

Authors: Malwina Sosnowska, Marta Kutwin, Barbara Strojny, Piotr Koczoń, Jarosław Szczepaniak, Jaśmina Bałaban, Karolina Daniluk, Sławomir Jaworski, André Chwalibog, Wiesław Bielawski and Ewa Sawosz

Experimental conditions influence the formation and composition of the corona around gold nanoparticles

Ovarian cancer is one of the deadliest gynecological malignancies. While the overall survival of ovarian cancer patients has slightly improved in recent years in the developed world, it remains clinically chal...

Authors: Md. Nazir Hossen, Chandra Kumar Elechalawar, Virginie Sjoelund, Kathleen Moore, Robert Mannel, Resham Bhattacharya and Priyabrata Mukherjee

Nanomedicine-mediated induction of immunogenic cell death and prevention of PD-L1 overexpression for enhanced hepatocellular carcinoma therapy

The present study aims to develop a nanoparticle encapsulating doxorubicin (DOX) and programmed death-ligand 1 (PD-L1) siRNA and evaluate its anti-tumor effects on hepatoma carcinoma (HCC).

Authors: Hanzhang Zhu, Weijiang Zhou, Yafeng Wan, Ke Ge, Jun Lu and Changku Jia

Nanomicelles potentiate histone deacetylase inhibitor efficacy in vitro

Amphiphilic block copolymers used as nanomicelle drug carriers can effectively overcome poor drug solubility and specificity issues. Hence, these platforms have a broad applicability in cancer treatment. In th...

Authors: S. Pisano, X. Wang, J. Garcia-Parra, A. Gazze, K. Edwards, V. Feltracco, Y. Hu, L. He, D. Gonzalez, L. W. Francis, R. S. Conlan and C. Li

Synthesis and analysis of silver–copper alloy nanoparticles of different ratios manifest anticancer activity in breast cancer cells

Breast cancer is therapeutically very challenging to treat as it has the main four known genetic alterations, which result in the existence of several phenotypes leading to the difference in the mode of therap...

Authors: Sara Al Tamimi, Sarmadia Ashraf, Tahir Abdulrehman, Aijaz Parray, Said A. Mansour, Yousef Haik and Shahnaz Qadri

Nanotechnology approaches to addressing HER2-positive breast cancer

Breast cancer is a major cause of cancer-associated deaths in the United States. It was estimated that 12% of women in the U.S. will develop invasive breast cancer in their lifetime. The human epidermal growth...

Authors: Bryan E. White, Molly K. White, Het Adhvaryu, Issam Makhoul, Zeid A. Nima, Alexandru S. Biris and Nawab Ali

Algae-meditated route to cuprous oxide (Cu₂O) nanoparticle: differential expression profile of MALAT1 and GAS5 LncRNAs and cytotoxic effect in human breast cancer

Breast cancer (BC), as the most widely recognized disease in women worldwide, represents about 30% of all cancers impacting women. This study was aimed to synthesize Cu₂O nanoparticles from the cystoseira myrica ...

Authors: Parisa Taherzadeh-Soureshjani and Mohammad Chehelgerdi

Cockle shell-derived aragonite calcium carbonate nanoparticle for targeting cancer and breast cancer stem cells

Cockle shell-derived aragonite calcium carbonate nanoparticles (CACNP) have demonstrated prospect as nano-sized drug carriers for targeting cancer cells. CACNP is biocompatible, biodegradable and its biomateri...

Authors: Kehinde Muibat Ibiyeye, Sherifat Banke Idris and Abu Bakar Zakaria Zuki

Enhanced MRI-guided radiotherapy with gadolinium-based nanoparticles: preclinical evaluation with an MRI-linac

The AGuIX^® (NH TherAguix) nanoparticle has been developed to enhance radiotherapy treatment and provide strong MR contrast. These two properties have previously been investigated separately and progressed to clin...

Authors: H. L. Byrne, G. Le Duc, F. Lux, O. Tillement, N. M. Holmes, A. James, U. Jelen, B. Dong, G. Liney, T. L. Roberts and Z. Kuncic

Elucidating the fate of nanoparticles among key cell components of the tumor microenvironment for promoting cancer nanotechnology

Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components...

Authors: Kyle Bromma, Aaron Bannister, Antonia Kowalewski, Leah Cicon and Devika B. Chithrani

Cancer research, treatment, and COVID-19

Authors: Steven A. Curley, Frederick Currell, Sunil Krishnan and Zeljka Krpetic

Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy

Doxorubicin-loaded hollow gold nanospheres (Dox@HAuNS) are a promising technology for simultaneous trans-arterial tumor-targeted chemotherapy delivery and thermal ablation. We evaluated the efficacy of intra-a...

Authors: Rahul A. Sheth, Xiaoxia Wen, Junjie Li, Marites P. Melancon, Xin Ji, Y. Andrew Wang, Cheng-Hui Hsiao, Diana S.-L. Chow, Elizabeth M. Whitley, Chun Li and Sanjay Gupta

Comparative study on contrast enhancement of Magnevist and Magnevist-loaded nanoparticles in pancreatic cancer PDX model monitored by MRI

The aim of this study was to compare contrast enhancement of Magnevist^® (gadopentate dimeglumine (Mag)) to that of PEGylated Magnevist^®-loaded liposomal nanoparticles (Mag-Lnps) in pancreatic cancer patient-deriv...

Authors: Kevin Affram, Taylor Smith, Shannon Helsper, Jens T. Rosenberg, Bo Han, Jose Trevino and Edward Agyare

Reducing the effective dose of cisplatin using gold nanoparticles as carriers

Nanotechnology is a frequent treatment for cancer. Nanomaterials are the vehicles which deliver drugs in smaller but equally effective quantities. The aim of this investigation is to synthesize gold nanopartic...

Authors: M. A. González-López, E. M. Gutiérrez-Cárdenas, C. Sánchez-Cruz, J. F. Hernández-Paz, I. Pérez, J. J. Olivares-Trejo and O. Hernández-González

Preferential drug delivery to tumor cells than normal cells using a tunable niosome–chitosan double package nanodelivery system: a novel in vitro model

We previously described the properties of a targeted drug delivery system (DDS) in a cell-free system. Here, in this comparative cell-based study (normal and tumor cells), we provide a quantitative analysis of...

Authors: Marzenna Wiranowska, Rupin Singh, Rana Falahat, Eva Williams, Joseph O. Johnson and Norma Alcantar

A [60]fullerene nanoconjugate with gemcitabine: synthesis, biophysical properties and biological evaluation for treating pancreatic cancer

The first-line chemotherapy drug that is used to treat pancreatic ductal adenocarcinoma is gemcitabine. Unfortunately, its effectiveness is hampered by its chemo-resistance, low vascularization and drug biodis...

Authors: Paweł Nalepa, Robert Gawecki, Grzegorz Szewczyk, Katarzyna Balin, Mateusz Dulski, Mieczysław Sajewicz, Anna Mrozek-Wilczkiewicz, Robert Musioł, Jaroslaw Polanski and Maciej Serda